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Table 7 Intramuscular immobilisation at four different thermal zones

From: Sedation and general anaesthesia of crocodilians: a systematic review

   

Time to immobilisation at given temperature [min]

Length of anaesthesia at given temperature [min]

Recovery from time of first injection [min]

  

Animals

Drug combination (dose [mg/kg])

Route

17–21 °C

22–26 °C

27–29 °C

30–32 °C

17–21 °C

22–26 °C

27–29 °C

30–32 °C

Reversal agent (dose[mg/kg])

Time [min]

 

References

A. mississi-ppiensis (n = 7)

Medetomidine (0.22)

Ketamine (10.0)

IM

TL

 

20 ± 9

   

112 ± 45

  

Atipamezole (1.18)

35 ± 22

[14]

Adult A. mississi-ppiensis (n = 9)

Medetomidine (0.13)

Ketamine (7.5)

IM

TL

 

27 ± 17

   

161 ± 35

  

Atipamezole (0.694)

38 ± 20

 

C. niloticus (n = 8)

Medetomidine (0.3)

Ketamine (15)

IM

TL

  

16 ± 8

   

MA

 

Atipamezole (1–3)

36 ± 12

 

[13]

C. porosus (n = 10) (2)

Medetomidine (0.5)

IM

TL

  

30

   

98 (1)

 

No reversal (n = 5)

120–135 (Post first injection)

[6]

Atipamezole (n = 5)

(2.5)

15 ± 6

 

C. johnstoni (n = 5)

Medetomidine (0.75)

IM

TL

  

30 ± 15

   

60 (1)

 

No reversal

90 (Post first injection)

 

C. porosus (n = 40) (3)

Medetomidine (0.5)

IM

TL

NI

35 ± 15

35 ± 10

15 ± 10

RV50

RV50

RV50

RV50

Atipamezole (2.5)

10 ± 5

 

[7]

A. mississi-ppiensis (n = 8)

Tiletamine-Zolazepam (15)

IM

TL

   

53 ± 31

   

131 (1)

No reversal

183 ± 34

(Post first injection)

[3]

A. mississi-ppiensis (n = 8)

Diazepam (0.4)

15 min

Atracurium (4)

IM

TL

  

39 ± 34

     

Neostigmine

No reversal (4)

317 ± 36

(Post first injection)

 

Adult

A. mississi-ppiensis (n = 28)

Diazepam (0.37)

20 min

Succinylcholine (0.24)

IM

HL

 

25–35

      

No reversal

180 + 

 

[4]

C. porosus (n = 10)

Midazolam (5)

IM

TL

   

15

    

No reversal

60

 

[1]

  1. All animals were juvenile unless else is indicated. A. mississippiensis = Alligator mississippiensis (Alligator), C. porosus = Crocodylus porosus (saltwater crocodile), C. johnstoni = Crocodylus johnstoni (freshwater crocodile), C. niloticus = Crocodylus niloticus (Nile crocodile)
  2. TL Thoracic limb, HL Hind limb, NI Not immobilised, RV50 reversed with atipamezole after 50 min
  3. MA = Maintained with inhalation anaesthesia and is therefore not applicable
  4. 1Calculated value, recovery time—time to immobilisation
  5. 2Animals injected in the pelvic limb and tail are not included in this Table
  6. 3Divided into four groups which were sedated at four different temperatures
  7. 4Three animals were attempted reversed with three different doses of neostigmine with no effect and reversal agents were not administered to the remainder of the animals